Uptake of Aβ 1-40- and Aβ 1-42-coated yeast by microglial cells: a role for LRP
نویسندگان
چکیده
منابع مشابه
Interaction between soluble Aβ-(1-40) monomer and Aβ-(1-42) fibrils probed by paramagnetic relaxation enhancement.
The most common isoforms of amyloid-β (Aβ) proteins are composed of 40 or 42 amino acid residues. While Aβ-(1-40) is the predominant species, Aβ-(1-42) is more fibrillogenic and neurotoxic, suggesting that Aβ-(1-42) plays a critical role in the initiation of amyloid fibril formation. We investigated the mechanisms by which soluble Aβ-(1-40) associates with preformed Aβ-(1-42) seeds. A paramagne...
متن کاملمدل ساز ی به روش شبیه سازی دینامیک مولکولی مونومر Aβ (1-42) و Aβ (1-40) ، به منظور مقایسه نقش آن‌ها در ایجاد بیماری آلزایمر
سابقه و هدف: مطالعه های آسیب‌شناختی، تشکیل پلاک‌های فیبری و توده‌های تجمع یافته پپتید آمیلوئید بتا (Aβ) را یکی از دلایل بیماری آلزایمر پیشنهاد کرده‌اند. از آنجا که این بیماری وابسته به ساختار فضایی پروتئین است در این مقاله به روش شبیه سازی دینامیک مولکولی مراحل آغازین تغییرهای کنفورماسیون دو مونومر از Aβ، Aβ (1-42) و Aβ (1-40) مورد بررسی قرار میگیرد. مواد و روش ها: ساختار NMR دو پپتید Aβ (...
متن کاملStructural Discrimination between Aβ(1-40) and Aβ(1-42) Peptides in Films with Vibrational Circular Dichroism Spectroscopy.
The secondary structure of full-length Aβ(1-40) and Aβ(1-42) peptides in films has been investigated with IR and vibrational circular dichroism (VCD) spectroscopy. From IR spectra, it is shown that the prepared films of Aβ(1-40) and Aβ(1-42) mainly comprise the β-sheet conformation that is characteristic of aggregated and fibrous Aβ. In the VCD spectra, the Aβ(1-42) film shows an intense and sh...
متن کاملDirect Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation
Insight into how amyloid β (Aβ) aggregation occurs in vivo is vital for understanding the molecular pathways that underlie Alzheimer's disease and requires new techniques that provide detailed kinetic and mechanistic information. Using noninvasive fluorescence lifetime recordings, we imaged the formation of Aβ(1-40) and Aβ(1-42) aggregates in live cells. For both peptides, the cellular uptake v...
متن کاملGinsenoside Rg1 attenuates oligomeric Aβ(1-42)-induced mitochondrial dysfunction.
Mitochondrial dysfunction is one of the major pathological changes seen in Alzheimer's disease (AD). Amyloid beta-peptide (Aβ), a neurotoxic peptide, accumulates in the brain of AD subjects and mediates mitochondrial and neuronal stress. Therefore, protecting mitochondrion from Aβ-induced toxicity holds potential benefits for halting and treating and perhaps preventing AD. Here, we report that ...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2004
ISSN: 0741-5400
DOI: 10.1189/jlb.1203620